PET-CT case of the month (06/09): GIST Treated with Gleevec
This case was compiled by Dr. David He, BCM
A 74yrs old male, status post resection of Gastrointestinal Stromal Tumor
(GIST) and history of adjuvant Gleevec (Imatinib mesylate) therapy 3 years
ago, was referred for PET-CT imaging because of interval increase in size of
the right lower quadrant soft tissue density mass, seen on a follow up CT scan.
(GIST) and history of adjuvant Gleevec (Imatinib mesylate) therapy 3 years
ago, was referred for PET-CT imaging because of interval increase in size of
the right lower quadrant soft tissue density mass, seen on a follow up CT scan.
PET-CT showed intense FDG uptake in the mass (maximum SUV 12.4) and
multiple smaller hypermetabolic lesions in the abdomen, consistent with neoplastic
involvement with GIST. Gleevec therapy was restarted and the follow up PET-CT
in 3 weeks demonstrated resolution of hypermetabolism in all lesions, suggesting
good response to therapy . The SUV of the RLQ mass decreased to 2.5.
multiple smaller hypermetabolic lesions in the abdomen, consistent with neoplastic
involvement with GIST. Gleevec therapy was restarted and the follow up PET-CT
in 3 weeks demonstrated resolution of hypermetabolism in all lesions, suggesting
good response to therapy . The SUV of the RLQ mass decreased to 2.5.
